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Amblema Rafinesque, 1820
Rafinesque, 1819. Jour. Phys. Chim. Hist. Nat. 88: 427.
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 314.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 29, 57.
(intro'd as sub-gen. of Unio Retzius, 1788)
Type species: Amblema costata Rafinesque, 1820 (sub. desig. by Rafinesque, 1831: ??) = Amblema plicata

Ameroda Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 319.
(error for Amesoda Rafinesque, 1820; renamed Amesodon Agassiz, 1846)

Amesoda Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 319.
(intro'd as sub-gen. of Cyclas Lamarck, 1799; renamed Amesodon Agassiz, 1846)
Type species: Cyclas similis Say, 1817 = Sphaerium simile

Aximedia Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 296.
Rafinesque, 1831. Continuation: 3.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 41, 75.
(intro'd as sub-gen. of Unio Retzius, 1788)
Type species: Unio (Aximedia) elliptica Rafinesque, 1820 (sub. desig. by Fischer, 1886: 1000) = Pleurobema clava

Dipsas Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 317.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 60.
(reference to Dipsas Leach, 1814)

Ellipsaria Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 303.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 47.
(intro'd as sub-gen. of Obliquaria Rafinesque, 1820)
Type species: Obliquaria (Ellipsaria) ellipsaria Rafinesque, 1820 (tautonomy) = Ellipsaria lineolata

Elliptio Rafinesque, 1819
Rafinesque, 1819. Jour. Phys. Chim. Hist. Nat. 88: 426.
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 291.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 29, 37.
(intro'd as sub-gen. of Unio Retzius, 1788)
Type species: Unio (Elliptio) nigra Rafinesque, 1820 (sub. desig. by Ortmann, 1912: 266) = Elliptio crassidens

Eurynia Rafinesque, 1820
Rafinesque, 1819. Jour. Phys. Chim. Hist. Nat. 88: 426. [nomen nudum]
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 297.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 29, 42.
(intro'd as sub-gen. of Unio Retzius, 1788)
Type species: Unio (Eurynia) dilatata Rafinesque, 1820 (sub. desig. by Herrmannsen, 1847: 436) = Eurynia dilatata

Hemistena Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 317.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 60.
(intro'd as sub-gen. of Anodonta Lamarck, 1799)
Type species: Anodonta (Lastena) lata Rafinesque, 1820 (monotypy) = Hemistena lata

Lampsilis Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 298.
Rafinesque, 1831. Continuation: 7.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 43, 84.
Type species: Unio ovatus Say, 1817 (sub. desig. by Herrmannsen, 1847: 575) = Lampsilis ovata

Lastena Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 316.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 59.
(intro'd as sub-gen. of Anodonta Lamarck, 1799; renamed Stenelasma Herrmannsen, 1849)
Type species: Anodonta (Lastena) ohiensis Rafinesque, 1820 (sub. desig. by Herrmannsen, 1847: 577, 58) = Potamilus ohiensis

Leptodea Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 295.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 40.
(intro'd as sub-gen. of Unio Retzius, 1788)
Type species: Unio (Leptodea) fragilis Rafinesque, 1820 (sub. desig. by Herrmannsen, 1847: 584) = Potamilus fragilis

Metaphera Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): ??.
(error for Metaptera Rafinesque, 1820)

Metaptera Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 299.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 44.
(new name for Proptera Rafinesque, 1819)
Type species: Unio alatus Say, 1817 (sub. desig. by Herrmannsen, 1847: 41) = Potamilus alatus

Obliquaria Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 301.
Rafinesque, 1831. Continuation: 3.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 46, 75.
Type species: Obliquaria (Quadrula) reflexa Rafinesque, 1820 (sub. desig. by Simpson, 1900: 610) = Obliquaria reflexa

Obovaria Rafinesque, 1819
Rafinesque, 1819. Jour. Phys. Chim. Hist. Nat. 88: 426.
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 310 [as ‘Obovaria’].
Rafinesque, 1864. [in] Binney & Tryon, reprint: 29, 54.
(intro'd as sub-gen. of Unio Retzius, 1788)
Type species: Unio retusa Lamarck, 1819 (ICZN) = Obovaria retusa

Phymeroda Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 319.
(error for Phymesoda Rafinesque, 1820)

Phymesoda Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 319.
(intro'd as sub-gen. of Cyclas Lamarck, 1799)

Plagiola Rafinesque, 1819
Rafinesque, 1819. Jour. Phys. Chim. Hist. Nat. 88: 426.
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 302 [as ‘Obliquaria (Plagiola)’].
Rafinesque, 1864. [in] Binney & Tryon, reprint: 29, 46.
(intro'd as sub-gen. of Unio Retzius, 1788)
Type species: Obliquaria (Plagiola) interrupta Rafinesque, 1820 (sub. desig. by Herrmannsen, 1847: 279) = Ptychobranchus fasciolaris

Pleurobema Rafinesque, 1819
Rafinesque, 1819. Jour. Phys. Chim. Hist. Nat. 88: 427.
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 313 [as ‘Pleurobema’].
Rafinesque, 1864. [in] Binney & Tryon, reprint: 29, 56.
(intro'd as sub-gen. of Unio Retzius, 1788)
Type species: Pleurobema mytiloides Rafinesque, 1820 (sub. desig. by Herrmannsen, 1847: 291) = Pleurobema clava

Polymesoda Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 319.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 61.
(intro'd as sub-gen. of Cyclas Lamarck, 1799)
Type species: Cyclas caroliniana Bosc, 1801 (orig. desig.) = Polymesoda caroliniana

Potamila Rafinesque, 1818
Rafinesque, 1818. Amer. Mon. Mag. 4: 107.
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 288.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 24, 35.
(error for Potamilus Rafinesque, 1818)

Quadrula Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 305.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 49.
(intro'd as sub-gen. of Obliquaria Rafinesque, 1820)
Type species: Obliquaria (Quadrula) quadrula Rafinesque, 1820 (sub. desig. by Herrmannsen, 1848: 384) = Quadrula quadrula

Rotundaria Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 308.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 52.
(intro'd as sub-gen. of Obliquaria Rafinesque, 1820)
Type species: Obliquaria (Rotundaria) subrotunda Rafinesque, 1820 (sub. desig. by Herrmannsen, 1848: 407) = Obovaria subrotunda

Scalenaria Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 309.
Rafinesque, 1831. Continuation: 3.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 52, 76.
(intro'd as sub-gen. of Obliquaria Rafinesque, 1820)
Type species: Obliquaria (Scalenaria) scalenia Rafinesque, 1820 (sub. desig. by Herrmannsen, 1848: 422) = Pleurobema clava

Scatenaria Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 419.
(error for Scalenaria Rafinesque, 1820)

Sintoxia Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 310.
Rafinesque, 1831. Continuation: 3.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 53, 75.
(intro'd as sub-gen. of Obliquaria Rafinesque, 1820)
Type species: Obliquaria (Sintoxia) sintoxia Rafinesque, 1820 (tautonomy) = Pleurobema sintoxia

Strophitus Rafinesque, 1820
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 316.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 59.
(intro'd as sub-gen. of Anodonta Lamarck, 1799)
Type species: Anodonta undulata Say, 1817 (monotypy) = Strophitus undulatus

Truncilla Rafinesque, 1819
Rafinesque, 1818. Amer. Mon. Mag. 4: 107 [nomen nudum].
Rafinesque, 1819. Jour. Phys. Chim. Hist. Nat. 88: 427.
Rafinesque, 1820. Ann. Gén. Sci. Phys. 5 (13): 300.
Rafinesque, 1831. Continuation: 4.
Rafinesque, 1864. [in] Binney & Tryon, reprint: 24, 29, 45, 76.
(intro'd as sub-gen. of Unio Retzius, 1788)
Type species: Truncilla truncata Rafinesque, 1820 (sub. desig. by Herrmannsen, 1849: 628) = Truncilla truncata